Journal article
Expectation violations enhance neuronal encoding of sensory information in mouse primary visual cortex
MF Tang, E Kheradpezhouh, CCY Lee, JE Dickinson, JB Mattingley, E Arabzadeh
Nature Communications | NATURE PORTFOLIO | Published : 2023
Abstract
The response of cortical neurons to sensory stimuli is shaped both by past events (adaptation) and the expectation of future events (prediction). Here we employed a visual stimulus paradigm with different levels of predictability to characterise how expectation influences orientation selectivity in the primary visual cortex (V1) of male mice. We recorded neuronal activity using two-photon calcium imaging (GCaMP6f) while animals viewed sequences of grating stimuli which either varied randomly in their orientations or rotated predictably with occasional transitions to an unexpected orientation. For single neurons and the population, there was significant enhancement in the gain of orientation-..
View full abstractGrants
Awarded by Canadian Institute for Advanced Research
Funding Acknowledgements
The Australian Research Council (ARC) provided support with a DECRA fellowship (DE210100508) to M.F.T., a DECRA fellowship (DE229199691) to C.L., the Centre of Excellence for Integrative Brain Function grant (CE140100007) to J.B.M. and E.A. and an ARC Discovery Project grant (DP1701009) to E.A. The National Health and Medical Research Council (NHMRC) provided support with a Project Grant to M.F.T., J.B.M. and E.A. (GNT1165337), an Ideas Grant to E.K., C.L. and E.A. (GNT1181643) and an NHMRC Investigator Grant (GNT2010141) to J.B.M. NVIDIA corporation donated a TITAN V GPU to M.F.T., and the Canadian Institute for Advanced Research (CIFAR) provided support to J.B.M.